What is the maximum time from last known normal for performing endovascular therapy?

The maximum time from last known normal for performing endovascular therapy is 24 hours. This duration is based on current guidelines and clinical evidence that support the use of endovascular therapy to treat acute ischemic stroke, particularly in patients who have an identifiable occlusion in the anterior circulation.

The rationale for this 24-hour window is that the chances of salvaging brain tissue and achieving a favorable clinical outcome diminish as the time from the onset of symptoms increases. By 24 hours, the risk of significant brain damage escalates, making intervention less effective. Any longer than this time frame typically results in a significantly decreased likelihood of re-establishing good cerebral perfusion, which is crucial for recovery.

Overall, the 24-hour limit balances the potential benefits of intervention against the risks involved, and it directs clinicians to act swiftly to optimize patient outcomes in acute stroke management.